4-{[4-氨基-6-(甲氧基甲基)-5-(7-甲氧基-5-甲基-1-苯并噻吩-2-基)吡咯[2,1-F]-[1,2,4]三嗪-7-基]甲基}哌嗪-2-酮

中文名	罗加替尼
英文名	BAY-1163877
别名	罗加替尼化合物ROGARATINIB 成纤维细胞生长因子受体(FGFR)抑制剂(ROGARATINIB) 4-{[4-氨基-6-(甲氧基甲基)-5-(7-甲氧基-5-甲基-1-苯并噻吩-2-基)吡咯[2,1-F]-[1,2,4]三嗪-7-基]甲基}哌嗪-2-酮
英文别名	BAY-1163877 Rogaratinib Rogaratinib (BAY1163877) 2-Piperazinone, 4-[[4-amino-6-(methoxymethyl)-5-(7-methoxy-5-methylbenzo[b]thien-2-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]methyl]- 4-{[4-amino-6-(methoxymethyl)-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,1-f]-[1,2,4]triazin-7-yl]methyl}piperazin-2-one
CAS	1443530-05-9
化学式	C23H26N6O3S
分子量	466.56
密度	1.48±0.1 g/cm3(Predicted)
溶解度	DMSO :2 mg/ml (需要超声波)
酸度系数	15.49±0.20(Predicted)
存储条件	-20°C
产品用途	Rogaratinib, also known as BAY-1163877, is an aberrant fibroblast growth factor receptor (FGFR) inhibitor. Rogaratinib is as an orally available, selective and potent inhibitor of FGFR-1, -2 and -3 kinase activity. FGFRs are a family of receptor tyrosine kinases, which may be upregulated in various tumor cell types and may be involved in tumor cell differentiation and proliferation, tumor angiogenesis, and tumor cell survival.
靶点	FGFR
上游原料	7-METHOXY-5-METHYLBENZO[B]THIOPHENE (2,2-diethoxyethyl)(2-methoxy-4-methylphenyl)sulfane 2-甲氧基-4-甲基苯磺酰氯 4-氨基-6-氰基吡咯并[1,2-F][1,2,4]三嗪甲醛
参考资料展开查看	1. Sylvia Grünewald , Oliver Politz , Sebastian Bender,et al.Rogaratinib: A potent and selective pan-FGFR inhibitor with broad antitumor activity in FGFR-overexpressing preclinical cancer models.Int J Cancer. 2019 Sep 1;145(5):1346-1357.2. Kim SM, et al. Activation of the Met kinase confers acquired drug resistance in FGFR-targeted lung cancer therapy. Oncogenesis. 2016 Jul 18;5(7):e241.

4-{[4-氨基-6-(甲氧基甲基)-5-(7-甲氧基-5-甲基-1-苯并噻吩-2-基)吡咯[2,1-F]-[1,2,4]三嗪-7-基]甲基}哌嗪-2-酮 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	2.143 ml	10.717 ml	21.433 ml
5 mM	0.429 ml	2.143 ml	4.287 ml
10 mM	0.214 ml	1.072 ml	2.143 ml
5 mM	0.043 ml	0.214 ml	0.429 ml

最后更新：2024-01-02 23:10:35

4-{[4-氨基-6-(甲氧基甲基)-5-(7-甲氧基-5-甲基-1-苯并噻吩-2-基)吡咯[2,1-F]-[1,2,4]三嗪-7-基]甲基}哌嗪-2-酮

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产品名: Rogaratinib 去供应商网站查看询盘
CAS: 1443530-05-9
产地: 上海
规格: R882376
价格: 1mg-1311,5mg-4275
库存: 现货
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产品名: Rogaratinib 去供应商网站查看询盘
CAS: 1443530-05-9
产地: 上海
规格: 98%
价格: 2mg 1500,5mg 2000,10mg 3200,25mg 4800,100mg 12800
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